Histological and functional study of gastric mucosa in tropical sprue.
نویسندگان
چکیده
In patients with tropical sprue studied both in Puerto Rico and South India, histological changes in gastric mucosa were noted in 67% and 90% of patients respectively (Floch, Thomassen, Cox, and Sheehy, 1963; Vaish, Sampathkumar, Jacob, and Baker, 1965). Besides histological abnormalities, a significant reduction in gastric acid output was also observed. However, these studies did not exclude the possibility that the two conditions might be separate entities coexisting in the same population. To exclude or confirm this possibility, the incidence of chronic gastritis in patients with tropical sprue should be compared with its incidence in general hospital patients with non-specific symptoms. The purpose of this communication was to study the histology and secretory function of the gastric mucosa in healthy control subjects, patients with 'vague' gastrointestinal symptoms showing normal jejunal mucosa and absorption tests, and patients with tropical sprue from Bombay. The results showed that the incidence of chronic gastritis in patients with tropical sprue was higher than in healthy control subjects but was comparable to that in patients with vague gastrointestinal symptoms. These results suggest that chronic gastritis and tropical sprue are perhaps two unrelated conditions coexisting in the same population.
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عنوان ژورنال:
- Gut
دوره 9 1 شماره
صفحات -
تاریخ انتشار 1968